Wow, I wish I had spoke with you instead of spending nearly 2 hours on the phone with support.
We have about 1500-1800 clients in total spread between 6 sites. The plan was to install the primary application server into our remote data center (which has no clients) and install full secondary application servers in each site.
I believe we would like to leverage the use of Patch Manager reporting for patch status and possibly for system inventory. The second would be less important since we have SCCM in our environment and it seems like much of that data would be redundant.
Thank you so much for your attention to this and your prompt response. It has really been difficult to try to intelligently plan out my deployment based on the complexity of my enterprise and the admin guide leaving me with tons of unanswered questions.